學術著作

*Wang YK, Huang SC, Chang CY, Huang WT, Liao MJ, Yip BS, Chou FP, Li TTH*, Wu TK* Multiple pleomorphic tetramers of thermostable direct hemolysin from Grimontia hollisae in exerting hemolysis and membrane binding. Sci. Rep. 9:9833, 2019.

*Shi J, Liu CL. Zhang B, Guo WJ, Zhu J, Chang CY, Zhao EJ, Jiao RH, Tan RX*, Ge HM* Genome mining and biosynthesis of kitacinnamycin as a STING activator. Chem. Sci., 2019, in press (https://pubs.rsc.org/en/Content/ArticleLanding/2019/SC/C9SC00815B#!divAbstract).

* Yan X, Chen J-J, Adhikari A, Teijaro CN, Ge H, Crnovcic I, Chang CY, Annaval T, Yang D, Rader C, Shen B* Comparative Studies of the Biosynthetic Gene Clusters for Anthraquinone-Fused Enediynes Shedding Light into the Tailoring Steps of Tiancimycin Biosynthesis. Organic Letters, 20, 5918-5921, 2018.

* Annaval T, Han L, Rudolf JD, Xie G, Yang D, Chang CY, Ma M, Crnovcic I, Miller MD, Soman J, Xu W, Phillips Jr GN, Shen B* Biochemical and structural characterization of TtnD, a prenylated FMN-dependent decarboxylase from the tautomycetin biosynthetic pathway. ACS Chemical Biology, 13, 2728-2738, 2018.

* Chang CY, Yan X, Crnovcic I, Annaval T, Chang C, Nocek B, Rudolf JD, Yang D, Hindra, Babnigg G, Joachimiak A, Phillips Jr GN, Shen B* Resistance to enediyne antitumor antibiotics by sequestration. Cell Chemical Biology 25, 1075-1085, 2018.

* Wang N, Rudolf JD, Dong LB, Osipiuk J, Hatzos-Skintges C, Endres M, Chang CY, Babnigg G, Joachimiak A, Phillips Jr GN, Shen B* Natural separation of the acyl-CoA ligase reaction results in a non-adenylating enzyme. Nature Chemical Biology, 14, 730-737, 2018.

* Chang CY, Lohman JR, Huang T, Michalska K, Bigelow L, Rudolf JD, Jedrzejczak R, Yan X, Ma M, Babnigg G, Joachimiak A, Phillips Jr GN, Shen B* Structural insights into the free-standing condensation enzyme SgcC5 catalyzing ester-bond formation in the biosynthesis of the enediyne antitumor antibiotic C-1027. Biochemistry, 57, 3278-3288, 2018.

* Hsu NS, Wang YL, Lin KH, Chang CF, Lyu SY, Hsu LJ, Liu YC, Chang CY, Wu CJ, Li TL* The mesomeric effect of thiazolium on non-Kekulé diradicals in Pichia stipitis transketolase. Angewandte Chemie-International Edition, 57, 1802-1807, 2018.

* Yan X, Hindra, Ge H, Yang D, Huang T, Crnovcic I, Chang CY, Fang SM, Annaval T, Zhu X, Huang Y, Zhao LX, Jiang Y, Duan Y, Shen B* Discovery of alternative producers of the enediyne antitumor antibiotic C-1027 with high titers. Journal of natural products, 81, 594-599, 2018.

* Guo X, Crnovcic I, Chang CY, Luo J, Lohman JR, Papinski M, Bechthold A, Horsman GP, Shen B* PokMT1 from the polyketomycin biosynthetic machinery of Streptomyces diastatochromogenes Tü6028 belongs to the emerging family of C-methyltransferases that act on CoA-activated aromatic substrates. Biochemistry, 57, 1003-1011, 2018.

* Yan X, Chen JJ, Adhikari A, Yang D, Crnovcic I, Wang N, Chang CY, Rader C, Shen B* Genome mining of Micromonospora yangpuensis DSM 45577 as a producer of an anthraquinone-fused enediyne. Organic Letters, 19, 6192-6195, 2017.

* Annaval T, Rudolf JD, Chang CY, Lohman JR, Kim Y, Bigelow L, Jedrzejczak R, Babnigg G, Joachimiak A, Phillips Jr GN, Shen B* Crystal structure of thioesterase SgcE10 supporting common polyene intermediates in 9- and 10-membered enediyne core biosynthesis. ACS Omega, 2, 5159-5169, 2017.

* Rudolf JD1, Chang CY1, Ma M, Shen B* Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. Natural Product Reports, 34, 1141-1172, 2017. (1contributed equally).

* Chang CY, Lohman JR, Cao H, Tan K, Rudolf JD, Ma M, Xu W, Bingman CA, Ragothaman M, Bigelow L, Babnigg G, Yan X, Joachimiak A, Phillips Jr GN, Shen B* Crystal structures of SgcE6 and SgcC, the two-component monooxygenase that catalyzes hydroxylation of a carrier protein-tethered substrate in biosynthesis of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus. Biochemistry, 55, 5142-5154, 2016.

* Huang Y, Tang GL, Pan G, Chang CY, Shen B* Characterization of the ketosynthase and acyl carrier protein domains at the LnmI nonribosomal peptide synthase-polyketide synthase interface for leinamycin biosynthesis. Organic letters, 18, 4288-4291, 2016.

* Rudolf JD, Dong LB, Cao H, Hatzos-Skintges C, Osipiuk J, Endres M, Chang CY, Ma M, Babnigg G, Joachimiak A, Phillips Jr GN, Shen B* Structure of the ent-copalyl diphosphate synthase PtmT2 from Streptomyces platensis CB00739, a bacterial type II diterpene synthase. Journal of the American Chemical Society, 138, 10905-10915, 2016.

* Huang T, Chang CY, Lohman JR, Rudolf JD, Kim Y, Chang C, Yang D, Ma M, Yan X, Crnovcic I, Bigelow L, Clancy S, Bingman CA, Yennamalli RM Babnigg G, Joachimiak A, Phillips Jr JN, Shen B* Crystal structure of SgcJ, an NTF2-like superfamily protein involved in biosynthesis of the 9-membered enediyne antitumor antibiotic C-1027. Journal of Antibiotics, 69, 731-740, 2016.

* Rudolf JD, Bigelow L, Chang C, Cuff ME, Lohman JR, Chang CY, Ma M, Yang D, Clancy S, Babnigg G, Joachimiak A, Phillips Jr GN, Shen B* Crystal structure of the zorbamycin-binding protein ZbmA, the primary self-resistance element in Streptomyces flavoviridis ATCC21892. Biochemistry, 54, 6842-6851, 2015.

* Lyu SY, Liu YC, Chang CY, Huang CJ, Chiu YH, Huang CM, Hsu NS, Lin KH, Wu CJ, Tsai MD, Li TL* Multiple complexes of long-aliphatic N-acyltransferases led to synthesis of 2,6-diacylated/2-acyl-substituted glycopeptide antibiotics effectively killing VRE. Journal of the American Chemical Society, 136, 10989-10995, 2014.

* Chang CY, Lyu SY, Liu YC, Hsu NS, Wu CC, Tang CF, Lin KH, Ho JY, Wu CJ, Tsai MD, Li TL* Biosynthesis of streptolidine involved two unexpected intermediates produced by a dihydroxylase and a cyclase through unusual mechanisms. Angewandte Chemie-International Edition, 53, 1943-1948, 2014.

* Wang KC, Lyu SY, Liu YC, Chang CY, Wu CJ, Li TT* "Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes", Acta Crystallogr Sect D Biol Crystallography,70,1401-1410,2014.

* Zou XW, Liu YC, Hsu NS, Huang CJ, Lyu SY, Chan HC, Chang CY, Yeh HW, Lin KH, Wu CJ, Tsai MD, Li TL* "Structure and mechanism of a nonhaem-iron SAM-dependent C-methyltransferase and its engineering to a hydratase and an O-methyltransferase", Acta Crystallogr Sect D Biol Crystallography, 70, 1549-1560,2014.

* Yang MT, Chang CH, Wang JM, Wu TK, Wang YK, Chang CY, Li TT* Crystal structure and inhibition studies of transglutaminase from Streptomyces mobaraense. Journal of Biological Chemistry, 286, 7301-7307, 2011.

* Chang CY, Hsieh YC, Wang TY, Chen YC, Wang YK, Chiang TW, Chen YJ, Chang CH, Chen CJ*, and Wu TK* Crystal structure and mutational analysis of aminoacylhistidine dipeptidase from Vibrio alginolyticus reveal a new architecture of M20 metallopeptidases. Journal of Biological Chemistry, 285, 39500-39510, 2010.

* Chang CY, Hsieh YC, Wang TY, Chen CJ*, Wu TK* Purification, crystallization and preliminary X-ray analysis of an aminoacylhistidine dipeptidase (PepD) from Vibrio alginolyticus. Acta Crystallogr Sect F Struct Biol Cryst Commun., 65, 216-218, 2009.

* Wang TY, Chen YC, Kao LW, Chang CY, Wang YK, Liu YH, Feng JM, Wu TK* Expression and characterization of the biofilm-related and carnosine-hydrolyzing aminoacylhistidine dipeptidase from Vibrio alginolyticus. FEBS J., 275, 5007-5020, 2008.

專利

* Teicoplanin analogs and uses thereof, Tsung-Lin Li, Syue-Yi Lyu, Yu-Chen Liu, and Chin-Yuan Chang, USA (PCT international application No. PCT/US2015/012914.)

* Li TL, Lyu SY, Liu YC, Chang CY. Taiwan patent - Teicoplanin analogs and uses thereof. Academia Sinica, Jan 28, 2015